Growth factor signal transduction defects in the cardiovascular system

Growth factor signal transduction defects in the cardiovascular system.

Growth factors are important molecules mediating both the development as well as adaptive and pathological changes within the cardiovascular system. Growth factors therefore mediate both beneficial and nonbeneficial effects. The beneficial actions include the improvement of endothelial function, stimulation of vascular repair, the formation of new capillaries (angiogenesis), and the growth of c...

Transforming growth factor signal transduction

Transforming growth factor beta1 (TGF1) is the prototypic member of a large family of structurally related pleiotropic-secreted cytokines that play a pivotal role in the control of differentiation, proliferation, and state of activation of many different cell types including immune cells. TGFfamily members have potent immunosuppressor activities in vitro and in vivo. These cytokines trigger the...

Aspects of growth factor signal transduction in the cell cytoplasm.

Signal transduction by the receptors for platelet-derived growth factor.

Platelet-derived growth factor (PDGF) is a connective tissue cell mitogen that originally was purified from human platelets, but recently has been found to be produced by many different cell types (reviewed by Ross et al. 1986; Heldin and Westermark, 1989). The in vivo function of PDGF remains speculative, but the fact that PDGF is released by platelets and by cells involved in the inflammatory...

Role of bcl-2 in growth factor triggered signal transduction.

The role of bcl-2 in the signal transduction pathway was assessed by studying the inositol phospholipid metabolism in fibroblasts transfected by this oncogene. The rate of accumulation of water soluble inositol phosphates in response to several growth factors was much higher in bcl-2 transfected NIH3T3 clones than in untransfected control. Moreover, bcl-2 transfected clones express elevated lev...